What is PGT? How genetic testing of embryos supports IVF treatment | Inspire IVF
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04 June 2026

What is PGT? How genetic testing of embryos supports IVF treatment

For those learning about PGT, here is a clear and concise explanation.

PGT (Preimplantation Genetic Testing) is a genetic analysis performed on embryos created through IVF before they are transferred back into the uterus.

The main purpose of PGT is to help identify embryos with normal genetic makeup (within the scope of current testing capabilities), supporting treatment planning and reducing the risk of certain genetic abnormalities.

How does PGT work?

Once the embryo reaches the blastocyst stage.

Embryologists carefully remove a small number of cells from its outer layer for genetic analysis. The embryo is then cryopreserved while the test results are being processed.

Once the results are available, the fertility specialist uses this information to help identify the most suitable embryo for transfer.

Types of PGT

PGT-A

Preimplantation Genetic Testing for Aneuploidy

  • Checks the number of chromosomes in an embryo
  • Helps detect conditions such as:
    • Trisomy 21 (Down syndrome)
    • Trisomy 18
    • Trisomy 13

PGT-A is the most commonly used type in IVF.

PGT-M

Preimplantation Genetic Testing for Monogenic Disorders

Used for couples who are carriers or have a family history of single-gene disorders, such as:

  • Thalassemia
  • Cystic Fibrosis
  • Spinal Muscular Atrophy (SMA)

PGT-SR

Preimplantation Genetic Testing for Structural Rearrangements

Recommended for individuals with chromosomal structural abnormalities, such as:

  • Balanced translocation
  • Robertsonian translocation

Who may benefit from PGT?

PGT may be considered in cases such as:

  • Age 35 and above
    The risk of chromosomal abnormalities increases with maternal age.
  • Recurrent pregnancy loss
    In some cases, chromosomal abnormalities may be one of the contributing factors.
  • Multiple unsuccessful IVF cycles
    PGT may help provide additional information to support treatment planning for the next cycle.
  • Family history of genetic disorders
    PGT-M may be considered based on the recommendation of a fertility specialist.

Does PGT improve IVF success rates?

PGT does not guarantee pregnancy.

However, in certain cases, it may help:

  • Select embryos with normal chromosomal profiles
  • Reduce the chance of transferring abnormal embryos
  • Improve treatment planning accuracy

Outcomes still depend on many factors, including:

  • Age
  • Egg quality
  • Sperm quality
  • Uterine health
  • Embryo quality

Technologies used in PGT testing

  • Next Generation Sequencing (NGS)
    A high-resolution genetic analysis method for comprehensive chromosome screening
  • Karyomapping
    A technique used for specific single-gene disorder analysis, often in PGT-M cases

PGT combined with modern IVF technologies at Inspire IVF

At Inspire IVF, PGT is integrated with advanced reproductive technologies such as:

  • AI Embryo Assessment
  • EmbryoScope (Time-Lapse Monitoring System)
  • ICSI
  • Telemedicine Consultation
  • Genetic Counseling

These tools help create a personalized treatment plan for each patient.

Why do international patients choose Thailand for PGT?

Thailand is a leading destination for fertility treatment in Asia, offering:

  • Advanced IVF and PGT technologies
  • Experienced fertility specialists
  • International-standard laboratories
  • Dedicated International Patient Services
  • Convenient travel access

Key standards to consider when choosing an IVF and PGT clinic

  • AACI Accreditation
  • TEMOS Certification
  • ISO 9001 Quality Management System

These reflect international standards in quality, safety, and patient care.

Conclusion

PGT is a genetic testing technology used alongside IVF to evaluate embryos before transfer into the uterus.

PGT testing helps support treatment planning in selected patient groups, especially those with advanced maternal age, recurrent miscarriage, or genetic risk factors.

However, the use of PGT should always be guided by a fertility specialist to ensure it is appropriate for each individual’s medical condition and treatment goals.

*Results may vary between individuals, and medical advice from a specialist is strongly recommended before treatment decisions.

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